From the Griffin Lab
Rajala R, Cleuren ACA, and Griffin CT. (2024) Acetaminophen overdose reveals PAR4 as a low-expressing but potent receptor on the hepatic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology, Oct 3. doi: 10.1161/ATVBAHA.124.321353. Online ahead of print. [Abstract]
Wu M-L, Wheeler K, Silasi R, Lupu F, and Griffin CT. (2024) Endothelial chromatin-remodeling enzymes regulate the production of critical ECM components during murine lung development. Arteriosclerosis, Thrombosis, and Vascular Biology, Aug; 44(8): 1784-1798. [Abstract]
Schafer CM, Martin-Almedina S, Kurylowicz K, Dutton N, Osuna-Almagro L, Wu ML, Johnson CF, Shah AV, Haskard DO, Buxton A, Willis E, Wheeler K, Turner S, Chlebicz M, Scott RP, Kovats S, Cleuren A, Birdsey GM, Randi AM1, and Griffin CT1. (2023) Cytokine-mediated degradation of the transcription factor ERG impacts the pulmonary vascular response to systemic inflammatory challenge. Arteriosclerosis, Thrombosis, and Vascular Biology, Aug; 43(8): 1412-1428. 1Corresponding Authors [Abstract]
Menendez M, Drozd A, Borawska K, Chmielewska JJ, Wu M-L, and Griffin CT. (2022) IL-1β impacts vascular integrity and lymphatic function in the embryonic omentum. Circulation Research, Feb 4; 130(3): 366-383. [Abstract]
Gao S, Menendez M, Kurylowicz K, and Griffin CT. (2021) Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells. PLoS ONE, Jun 21; 16(6): e0253519. [Abstract]
Gao S, and Griffin CT. (2021) RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis. Angiogenesis, Aug; 24(3): 519-531. [Abstract]
Schafer CM, Gurley JM, Kurylowicz K, Lin PK, Chen W, Elliott MH, Davis GE, Bhatti F, and Griffin CT. (2020) An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression. Proceedings of the National Academy of Sciences USA, Oct 20; 117(42): 26494-26502. [Abstract]
Xie J, Gao S, Schafer C, Colijn S, Muthukumar V, and Griffin CT. (2020) The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development. PLoS ONE, Jul 13; 15(7): e0235799. [Abstract]
Colijn S, Muthukumar V, Xie J, Gao S, and Griffin CT. (2020) Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Disease Models & Mechanisms, Jan 24; 13(1):dmm041962. (Selected cover image) [Abstract]
Colijn S1, Gao S1, Ingram KG1, Menendez M, Muthukumar V, Silasi-Mansat R, Chmielewska JJ, Hinsdale M, Lupu F, and Griffin CT. (2020) The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture. Cell Death & Differentiation, 27(2): 618-631. 1Equal contribution [Abstract]
Menendez MT, and Griffin CT. (2018) Characterizing epigenetic changes in endothelial cells. Methods in Molecular Biology, 1846:335-344. (Invited Chapter) [Abstract]
Gao S, Silasi-Mansat R, Behar A, Lupu F, and Griffin CT. (2018) Excessive plasmin compromises hepatic sinusoidal vascular integrity after acetaminophen overdose. Hepatology, 68(5): 1991-2003. [Abstract]
Menendez MT1, Ong EC1, Shepherd BT, Muthukumar V, Silasi-Mansat R, Lupu F, and Griffin CT. (2017) BRG1 (Brahma-Related Gene 1) promotes endothelial Mrtf transcription to establish embryonic capillary integrity. Arteriosclerosis, Thrombosis, and Vascular Biology, 37(9):1674-1682. 1Equal contribution [Abstract]
Griffin CT, and Gao S. (2017) Building discontinuous liver sinusoidal vessels. The Journal of Clinical Investigation, 127(3): 790-792. (Invited Commentary) [Abstract]
Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, and Griffin CT. (2016) CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. The Journal of Clinical Investigation, 126(6): 2254-66. [Abstract]
Wiley MM, Muthukumar V, Griffin TM, and Griffin CT. (2015) SWI/SNF Chromatin-Remodeling Enzymes Brahma-Related Gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. Journal of the American Heart Association, 4(4): e001972. [Abstract]
Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, and Griffin CT. (2013) The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis. PLoS Genetics, 9: e1004031. [Abstract]
Davis RB, Curtis CD, and Griffin CT. (2013) BRG1 promotes Coup-TFII expression and venous specification during embryonic vascular development. Development, 140(6): 1272-1281. [Abstract]
Curtis CD, Davis RB, Ingram KG, and Griffin CT. (2012) Chromatin-remodeling complex specificity and embryonic vascular development. Cellular and Molecular Life Sciences, 69(23): 3921-3931. (Invited Review) [Abstract]
Curtis CD, and Griffin CT. (2012) The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Molecular and Cellular Biology, 32(7): 1312-1320. [Abstract]
Griffin CT1,2, Curtis CD2, Davis RB, Muthukumar V, and Magnuson T. (2011) The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proceedings of the National Academy of Sciences USA, 108(6): 2282-2287. 1Corresponding author; 2Equal contribution [Abstract]
Collaborative Publications
Kemp SS, Penn MR, Koller GM, Griffin CT, Davis GE. (2022) Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression. Frontiers in Cell and Developmental Biology, 10:937982. [Abstract]
de Castro RO, Carbajal A, Previato de Almeida LP, Goitea V, Griffin CT, Pezza RJ. (2022) Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development. Epigenetics and Chromatin, 15(1): 16. [Abstract]
Lin PK, Salvador J, Xie J, Aguera KN, Koller GM, Kemp SS, Griffin CT, and Davis GE. (2021) Selective and marked blockade of endothelial sprouting behavior using paclitaxel and related pharmacologic agents. American Journal of Pathology, 191(12): 2245-2264. [Abstract]
Koller GM, Schafer C, Kemp SS, Aguera KN, Lin PK, Forgy JC, Griffin CT, and Davis GE. (2020) Proinflammatory mediators, IL (Interleukin)-1β, TNF (Tumor Necrosis Factor) α, and thrombin directly induce capillary tube regression. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(2): 365-377. [Abstract]
Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, and Csiszar A. (2018) Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nature Reviews Cardiology, 15(9): 555-565. (Invited Review) [Abstract]
Kondo Y, Fu J, Wang H, Hoover C, McDaniel M, Steet R, Patra C, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, and Xia L. (2018) Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight, 3(14): e121596. [Abstract]
Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, and Chen H. (2014) Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Science Signaling, 7(347): ra97. [Abstract]
Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, and Chen H. (2014) Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by Epsin deficiency. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(2): 331-337. [Abstract]
Chen H, Griffin C, Xia L, Srinivasan RS. (2014) Molecular and cellular mechanisms of lymphatic vascular maturation. Microvascular Research, 96(16-22). (Invited Review) [Abstract]
McBride J, Jenkins A, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin C, Aston CE, Lyons T, Tomasek JJ, and Ma J. (2014) Elevated circulation levels of an anti-angiogenic SERPIN in patients with diabetic microvascular complications impairs wound healing through suppression of Wnt signaling. Journal of Investigative Dermatology, 134(6): 1725-1734. [Abstract]
Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, and Tucker PW. (2011) The ARID family transcription factor Bright is required for both hematopoietic stem cell and B lineage development. Molecular and Cellular Biology, 31(5): 1041-1053. [Abstract]
Selected Publications from Courtney’s Training
Griffin CT, Brennan J, and Magnuson T. (2008) The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development. Development, 135(3): 493-500. [Abstract]
Griffin CT, Trejo J, and Magnsuon T. (2005) Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proceedings of the National Academy of Sciences USA, 102(42): 15167-15172. [Abstract]
Schwarz DG, Griffin CT, Schneider EA, Yee D, and Magnuson T. (2002) Genetic analysis of sorting nexins 1 and 2 reveals a redundant and essential function in mice. Molecular Biology of the Cell, 13(10): 3588-3600. [Abstract]
Griffin CT, Srinivasan Y, Zheng YW, Huang W, and Coughlin SR. (2001) A role for thrombin receptor signaling in endothelial cells during embryonic development. Science, 293(5535), 1666-1670. [Abstract] (This article was the subject of a short commentary: Carmeliet, P., Clotting Factors Build Blood Vessels, Science, Vol. 293 (2001) 1602-1604)
Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, and Coughlin SR. (1997) Protease-activated receptor 3 is a second thrombin receptor in humans. Nature, 386(6624): 502-506. [Abstract]