Our ongoing analysis of embryos with mutated chromatin-remodeling enzymes has piqued our interest in the programmed necrosis (necroptosis) cell death pathway. Our research indicates that this form of cell death causes embryonic vascular fragility and rupture. We are leveraging NIH funding (R01HL134778) to study causes and effects of endothelial cell necroptosis in development and disease. Stay tuned as the lab publishes its first papers in this exciting new field.
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